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Papers Organized by Theme

(or see by Date for a single listing of all papers)

Modeling
Empirical
Basal Ganglia and Frontal Cortex Contributions to Reinforcement Learning and Decision Making
Working Memory and Cognitive Control in the Prefrontal Cortex and Basal Ganglia
Learning, Memory and Generalization in the Hippocampus
Commentaries

Papers Listed by Date

(or see by Theme)

[PDF] [Abstract] Collins, A.G.E. & Frank, M.J. (2012). How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis. European Journal of Neuroscience, 35, 1024-1035.
[PDF] [Abstract] Cavanagh, J.F., Figueroa, C.M., Cohen, M.X. & Frank, M.J. (in press). Frontal theta reflects uncertainty and unexpectedness during exploration and exploitation. Cerebral Cortex.
[Main PDF] [Supp PDF] [Abstract] Badre, D., Doll, B.B., Long, N.M. & Frank, M.J. (2012). Rostrolateral prefrontal cortex and individual differences in uncertainty-driven exploration. Neuron, 73, 595-607.
[Main PDF] [Supp PDF] [Abstract] Gold, J.M., Waltz, J.A., Matveeva, T.M., Kasanova, Z., Strauss, G.P., Herbener, E.S., Collins, A.G.E. & Frank, M.J. (2012). Negative symptoms and the failure to represent the expected reward value of actions: Behavioral and computational modeling evidence. Archives of General Psychiatry, 69, 129-138.
[Main PDF] [Supp PDF] [Abstract] Cavanagh, J.F., Wiecki, T.V., Cohen, M.X., Figueroa, C.M., Samanta, J., Sherman, S.J. & Frank, M.J. (2011). Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold. Nature Neuroscience, 14,.
[PDF] [Abstract] Ratcliff, R. & Frank, M.J. (2012). Reinforcement-based decision making in corticostriatal circuits: Mutual constraints by neurocomputational and diffusion models. Neural Computation, 24, 1186-1229.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J. & Badre, D. (2012). Mechanisms of hierarchical reinforcement learning in corticostriatal circuits 1: Computational analysis. Cerebral Cortex, 22, 509-526.
[PDF] [Abstract] Badre, D. & Frank, M.J. (2012). Mechanisms of hierarchical reinforcement learning in corticostriatal circuits 2: Evidence from fMRI. Cerebral Cortex, 22, 527-536.
[PDF] [Abstract] Doll, B.B., Hutchison, K.E. & Frank, M.J. (2011). Dopaminergic genes predict individual differences in susceptibility to confirmation bias. Journal of Neuroscience 6188-6198.
[PDF] [Abstract] Frank, M.J. (2011). Computational models of motivated action selection in corticostriatal circuits. Current Opinion in Neurobiology, 21, 381-386.
[PDF] [Abstract] Maia, T.V. & Frank, M.J. (2011). From reinforcement learning models to psychiatric and neurological disorders. Nature Neuroscience, 14, 154-162.
[PDF] [Abstract] Frank, M.J. & Fossella, J.A. (2011). Neurogenetics and pharmacology of learning, motivation and cognition. Neuropsychopharmacology Reviews, 36, 133-152.
[PDF] [Abstract] Cavanagh, J.F., Bismark, A.J., Frank, M.J. & Allen, J.J.B. (2011). Larger error signals in major depression are associated with better avoidance learning. Frontiers in Psychology | Cognition, 2,.
[PDF] [Abstract] Cockburn, J. & Frank, M.J. (2011). Reinforcement learning, conflict monitoring, and cognitive control: An integrative model of cingulate-striatal interactions and the ERN. R. Mars, J. Sallet, M. Rushworth & N. Yeung (Eds) Neural Basis of Motivational and Cognitive Control, 311-331, Cambridge: The MIT Press.
[PDF] [Abstract] Strauss, G.P., Frank, M.J., Waltz, J.A., Kasanova, Z., Herbener, E.S. & Gold, J.M. (2011). Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia. Biological Psychiatry, 69, 424-431.
[PDF] [Abstract] Wietzikoski, E.C., Boschen, S.L., Miyoshi, E., Bortolanza, M., Mendes dos Santos, L., Frank, M.J., Brandao, M.L., Winn, P. & Da Cunha, C. (in press). Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses. Psychopharmacology.
[PDF] [Abstract] Kasanova, Z., Waltz, J.A., Strauss, G.P., Frank, M.J. & Gold, J.M. (2011). Optimizing vs matching: Response strategy in a probabilistic learning task is associated with negative symptoms of schizophrenia. Schizophrenia Research, 127, 215-222.
[PDF] [Abstract] Waltz, J.A., Frank, M.J., Wiecki, T.V. & Gold, J.M. (2011). Altered probabilistic learning and response biases in schizophrenia: Behavioral evidence and neurocomputational modeling. Neuropsychology, 25,.
[PDF] [Abstract] Cavanagh, J.F., Frank, M.J. & Allen, J.J.B. (2011). Social stress reactivity alters reward and punishment learning. Social Cognitive & Affective Neuroscience, 6, 311-320.
[PDF] [Abstract] Wiecki, T.V. & Frank, M.J. (2010). Neurocomputational models of motor and cognitive deficits in Parkinson's disease. Progress in Brain Research, 183, 275-297.
[PDF] [Abstract] Cavanagh, J.F., Frank, M.J., Klein, T.J. & Allen, J.J.B. (2010). Frontal theta links prediction errors to behavioral adaptation in reinforcement learning. NeuroImage, 49, 3198-3209.
[PDF] [Abstract] Cavanagh, J.F., Grundler, T.O.J., Frank, M.J. & Allen, J.J.B. (2010). Altered cingulate sub-region activation accounts for task-related dissociation in ERN amplitude as a function of obsessive-compulsive symptoms. Neuropsychologia, 48, 2098-2109.
[PDF] [Abstract] Robinson, O.J., Frank, M.J., Sahakian, B.J. & Cools, C. (2010). Dissociable responses to punishment in distinct striatal regions during reversal learning. NeuroImage 1459-1467.
[PDF] [Abstract] Strauss, G.P., Robinson, B.M., Waltz, J.A., Frank, M.J., Kasanova, Z., Herbener, E.S. & Gold, J.M. (in press). Patients with schizophrenia demonstrate inconsistent preference judgments for affective and nonaffective stimuli. Schizophrenia Bulletin.
[PDF] [Abstract] Samson, R.D., Frank, M.J. & Fellous, J. (2010). Computational models of reinforcement learning: the role of dopamine as a reward signal. Cognitive Neurodynamics, 4, 91-105.
[PDF] [Abstract] Hazy, T.E., Frank, M.J. & O'Reilly, R.C. (2010). Neural mechanisms of acquired phasic dopamine responses in learning. Neuroscience & Biobehavioral Reviews, 34, 701-720.
[PDF] [Abstract] Chase, H.W., Frank, M.J., Michael, A., Bullmore, E.T., Sahakian, B. & Robbins, T.W. (2010). Approach and avoidance learning in patients with major depression and healthy controls: relation to anhedonia. Psychological Medicine, 40, 433-440.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Doll, B.B., Oas-Terpstra, J. & Moreno, F. (2009). Prefrontal and striatal dopaminergic genes predict individual differences in exploration and exploitation. Nature Neuroscience, 12, 1062-1068.
[PDF] Daw, N.D. & Frank, M.J. (2009). Reinforcement learning and higher level cognition: Introduction to special issue. Cognition, 113, 259-261.
[PDF] Frank, M.J. & Surmeier, D.J. (2009). Do substantia nigra dopaminergic neurons differentiate between reward and punishment? (Commentary on Matsumoto & Hikosaka, 2009). Journal of Molecular Cell Biology, 1, 15-16.
[email me for PDF] [Abstract] Doll, B.B. & Frank, M.J. (2009). The basal ganglia in reward and decision making: computational models and empirical studies. J. Dreher & L. Tremblay (Eds) Handbook of Reward and Decision Making, 399-425, Oxford: Academic Press.
[PDF] [Abstract] Frank, M.J. & Hutchison, K.E. (2009). Genetic contributions to avoidance-based decisions: Striatal D2 receptor polymorphisms. Neuroscience, 164, 131-140.
[PDF] Frank, M.J. (2009). Slave to the striatal habit (Commentary on Tricomi et al, 2009). European Journal of Neuroscience, 29, 2223-2224.
[PDF] [Abstract] Gruendler, T.O.J., Cavanagh, J.F., Figueroa, C.M., Frank, M.J. & Allen, J.J.B. (2009). Task-related dissociation in ERN amplitude as a function of obsessive-compulsive symptoms. Neuropsychologia, 47, 1978-1987.
[Main PDF] [Supp PDF] [Abstract] Chatham, C.H., Frank, M.J. & Munakata, Y. (2009). Pupillometric and behavioral markers of a developmental shift in the temporal dynamics of cognitive control. Proceedings of the National Academy of Sciences, 106, 5529-5533.
[Main PDF] [Supp PDF] [Abstract] Wiecki, T.V., Riedinger, K., Meyerhofer, A., Schmidt, W. & Frank, M.J. (2009). A neurocomputational account of catalepsy sensitization induced by D2-receptor-blockade in rats: Context-dependency, extinction, and renewal. Psychopharmacology, 204, 265--277.
[PDF] [Abstract] Doll, B.B., Jacobs, W.J., Sanfey, A.G. & Frank , M.J. (2009). Instructional control of reinforcement learning: A behavioral and neurocomputational investigation. Brain Research, 1299, 74-94.
[PDF] [Abstract] Frank, M.J., Cohen, M.X. & Sanfey, A.G. (2009). Multiple systems in decision making: A neurocomputational perspective. Current Directions in Psychological Science, 18, 73--77.
[Main PDF] [Supp PDF] [Abstract] Cools, R., Frank, M.J., Gibbs, S.E., Miyakawa, A., Jagust, W. & D'Esposito, M. (2009). Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration. Journal of Neuroscience, 29, 1538-1543.
[PDF] [Abstract] Cohen, M.X. & Frank, M.J. (2009). Neurocomputational models of basal ganglia function in learning, memory and choice. Behavioural Brain Research, 199, 141-156.
[PDF] [Abstract] Moustafa, A.A., Cohen, M.X., Sherman, S.J. & Frank, M.J. (2008). A role for dopamine in temporal decision making and reward maximization in Parkinsonism. Journal of Neuroscience, 28, 12294-12304.
[PDF] Frank, M.J. (2008). Schizophrenia: A computational reinforcement learning perspective. Schizophrenia Bulletin, 34, 1008-1011.
[PDF] [Abstract] Moustafa, A.A., Sherman, S.J. & Frank, M.J. (2008). A dopaminergic basis for working memory, learning and attentional shifting in Parkinsonism. Neuropsychologia, 46, 3144-3156.
[PDF] [Abstract] Santesso, D., Evins, A., Frank, M., Cowman, E. & Pizzagalli, D. (2009). Single dose of a dopamine agonist impairs reinforcement learning in humans: Converging evidence from electrophysiology and computational modeling of striatal-cortical function. Human Brain Mapping, 30, 1963--1976.
[PDF] [Abstract] Frank, M.J. & Kong, L. (2008). Learning to Avoid in Older Age. Psychology and Aging, 23, 392-398.
[PDF] [Abstract] Frank, M.J., O'Reilly, R. & Curran, T. (2008). Midazolam, hippocampal function, and transitive inference: Reply to Greene. Behavioral and Brain Functions, 4, 5.
[PDF] [Abstract] Pizzagalli, D.A., Evins, A.E., Schetter, E.C., Frank, M.J., Pajtas, P.E., Santesso, D.L. & Culhane, M. (2008). Single dose of a dopamine agonist impairs reinforcement learning in humans: Behavioral evidence from a laboratory-based measure of reward responsiveness. Psychopharmacology, 196, 221--232.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Samanta, J., Moustafa, A.A. & Sherman, S.J. (2007). Hold your horses: Impulsivity, deep brain stimulation and medication in Parkinsonism. Science, 318, 1309-1312. [Journal Homepage]
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Moustafa, A.A., Haughey, H., Curran, T. & Hutchison, K. (2007). Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning. Proceedings of the National Academy of Sciences, 104, 16311-16316. [Journal Homepage]
[PDF] [Abstract] Frank, M.J., D'Lauro, C. & Curran, T. (2007). Cross-task individual differences in error processing: Neural, electrophysiological and genetic components. Cognitive, Affective and Behavioral Neuroscience, 7, 297-308.
[PDF] [Abstract] Frank, M.J., Santamaria, A., O'Reilly, R. & Willcutt, E. (2007). Testing computational models of dopamine and noradrenaline dysfunction in Attention Deficit/Hyperactivity Disorder. Neuropsychopharmacology, 32, 1583-99.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Scheres, A. & Sherman, S.J. (2007). Understanding decision making deficits in neurological conditions: Insights from models of natural action selection. Philosophical Transactions of the Royal Society - B, 362, 1641-1654. [Journal Homepage]
[Main PDF] [Supp PDF] [Abstract] Hazy, T.E., Frank, M.J. & O'Reilly, R.C. (2007). Toward an executive without a homunculus: Computational models of the prefrontal cortex/basal ganglia system. Philosophical Transactions of the Royal Society - B, 362, 1601-1613. [Journal Homepage]
[Main PDF] [Commentary] [Abstract] Waltz, J.A., Frank, M.J., Robinson, B.M. & Gold, J.M. (2007). Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction. Biological Psychiatry, 62, 756-764.
[PDF] [Abstract] Aron, A.R., Behrens, T.E., Smith, S., Frank, M.J. & Poldrack, R.A. (2007). Triangulating a cognitive control network using diffusion-weighted MRI and functional MRI. Journal of Neuroscience, 27, 3743-52.
[PDF] [Abstract] O'Reilly, R.C., Frank, M.J., Hazy, T.E. & Watz, B. (2007). PVLV: The Primary Value and Learned Value Pavlovian learning algorithm. Behavioral Neuroscience, 121, 31-49.
[PDF] [Abstract] Frank, M.J. (2006). Hold your horses: A dynamic computational role for the subthalamic nucleus in decision making. Neural Networks, 19, 1120-1136.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J. & O'Reilly, R.C. (2006). A mechanistic account of striatal dopamine function in human cognition: Psychopharmacological studies with cabergoline and haloperidol. Behavioral Neuroscience, 120, 497-517.
[PDF] [Abstract] Frank, M.J. & Claus, E.D. (2006). Anatomy of a decision: Striato-orbitofrontal interactions in reinforcement learning, decision making and reversal. Psychological Review, 113, 300-326.
[PDF] [Abstract] Frank, M.J., OReilly, R.C. & Curran, T. (2006). When memory fails, intuition reigns: Midazolam enhances implicit inference in humans. Psychological Science, 17, 700-707.
[PDF] [Abstract] O'Reilly, R.C. & Frank, M.J. (2006). Making working memory work: A computational model of learning in the frontal cortex and basal ganglia. Neural Computation, 18, 283-328.
[PDF] [Abstract] Hazy, T.E., Frank, M.J. & O'Reilly, R.C. (2006). Banishing the homunculus: Making working memory work. Neuroscience, 139, 105--118.
[PDF] [Abstract] Frank, M.J., Rudy, J.W., Levy, W.B. & O'Reilly, R.C. (2005). When logic fails: Implicit transitive inference in humans. Memory and Cognition, 33, 742--750.
[PDF] [Abstract] Frank, M.J. (2005). Dynamic dopamine modulation in the basal ganglia: A neurocomputational account of cognitive deficits in medicated and non-medicated Parkinsonism. Journal of Cognitive Neuroscience, 17, 51-72.
[PDF] [Abstract] Frank, M.J., Woroch, B.S. & Curran, T. (2005). Error-related negativity predicts reinforcement learning and conflict biases. Neuron, 47, 495-501.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Seeberger, L. & O'Reilly, R.C. (2004). By carrot or by stick: Cognitive reinforcement learning in Parkinsonism. Science, 306, 1940-1943.
[PDF] [Abstract] Frank, M.J. (2004). Dynamic dopamine modulation of striato-cortical circuits in cognition: Converging neuropsychological, psychopharmacological and computational studies. Phd Thesis, University of Colorado at Boulder, Boulder, CO
[PDF] [Abstract] Atallah, H.E., Frank, M.J. & O'Reilly, R.C. (2004). Hippocampus, cortex and basal ganglia: Insights from computational models of complementary learning systems. Neurobiology of Learning and Memory, 82/3, 253-67.
[PDF] [Abstract] Frank, M.J., Rudy, J.W. & O'Reilly, R.C. (2003). Transitivity, flexibility, conjunctive representations and the hippocampus: II. A computational analysis. Hippocampus, 13, 341-354.
[PDF] [Abstract] Frank, M.J., Loughry, B. & O'Reilly, R.C. (2001). Interactions between the frontal cortex and basal ganglia in working memory: A computational model. Cognitive, Affective, and Behavioral Neuroscience, 1, 137-160.

Papers Organized by Theme

(Some papers apply to multiple themes; below listings generated automatically via computer script -- Please let me know if a link is broken!)

Modeling

[PDF] [Abstract] Collins, A.G.E. & Frank, M.J. (2012). How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis. European Journal of Neuroscience, 35, 1024-1035.
[PDF] [Abstract] Cavanagh, J.F., Figueroa, C.M., Cohen, M.X. & Frank, M.J. (in press). Frontal theta reflects uncertainty and unexpectedness during exploration and exploitation. Cerebral Cortex.
[Main PDF] [Supp PDF] [Abstract] Badre, D., Doll, B.B., Long, N.M. & Frank, M.J. (2012). Rostrolateral prefrontal cortex and individual differences in uncertainty-driven exploration. Neuron, 73, 595-607.
[Main PDF] [Supp PDF] [Abstract] Gold, J.M., Waltz, J.A., Matveeva, T.M., Kasanova, Z., Strauss, G.P., Herbener, E.S., Collins, A.G.E. & Frank, M.J. (2012). Negative symptoms and the failure to represent the expected reward value of actions: Behavioral and computational modeling evidence. Archives of General Psychiatry, 69, 129-138.
[Main PDF] [Supp PDF] [Abstract] Cavanagh, J.F., Wiecki, T.V., Cohen, M.X., Figueroa, C.M., Samanta, J., Sherman, S.J. & Frank, M.J. (2011). Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold. Nature Neuroscience, 14,.
[PDF] [Abstract] Ratcliff, R. & Frank, M.J. (2012). Reinforcement-based decision making in corticostriatal circuits: Mutual constraints by neurocomputational and diffusion models. Neural Computation, 24, 1186-1229.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J. & Badre, D. (2012). Mechanisms of hierarchical reinforcement learning in corticostriatal circuits 1: Computational analysis. Cerebral Cortex, 22, 509-526.
[PDF] [Abstract] Cockburn, J. & Frank, M.J. (2011). Reinforcement learning, conflict monitoring, and cognitive control: An integrative model of cingulate-striatal interactions and the ERN. R. Mars, J. Sallet, M. Rushworth & N. Yeung (Eds) Neural Basis of Motivational and Cognitive Control, 311-331, Cambridge: The MIT Press.
[PDF] [Abstract] Wiecki, T.V. & Frank, M.J. (2010). Neurocomputational models of motor and cognitive deficits in Parkinson's disease. Progress in Brain Research, 183, 275-297.
[PDF] [Abstract] Samson, R.D., Frank, M.J. & Fellous, J. (2010). Computational models of reinforcement learning: the role of dopamine as a reward signal. Cognitive Neurodynamics, 4, 91-105.
[PDF] [Abstract] Hazy, T.E., Frank, M.J. & O'Reilly, R.C. (2010). Neural mechanisms of acquired phasic dopamine responses in learning. Neuroscience & Biobehavioral Reviews, 34, 701-720.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Doll, B.B., Oas-Terpstra, J. & Moreno, F. (2009). Prefrontal and striatal dopaminergic genes predict individual differences in exploration and exploitation. Nature Neuroscience, 12, 1062-1068.
[email me for PDF] [Abstract] Doll, B.B. & Frank, M.J. (2009). The basal ganglia in reward and decision making: computational models and empirical studies. J. Dreher & L. Tremblay (Eds) Handbook of Reward and Decision Making, 399-425, Oxford: Academic Press.
[Main PDF] [Supp PDF] [Abstract] Wiecki, T.V., Riedinger, K., Meyerhofer, A., Schmidt, W. & Frank, M.J. (2009). A neurocomputational account of catalepsy sensitization induced by D2-receptor-blockade in rats: Context-dependency, extinction, and renewal. Psychopharmacology, 204, 265--277.
[PDF] [Abstract] Doll, B.B., Jacobs, W.J., Sanfey, A.G. & Frank , M.J. (2009). Instructional control of reinforcement learning: A behavioral and neurocomputational investigation. Brain Research, 1299, 74-94.
[PDF] [Abstract] Cohen, M.X. & Frank, M.J. (2009). Neurocomputational models of basal ganglia function in learning, memory and choice. Behavioural Brain Research, 199, 141-156.
[PDF] [Abstract] Moustafa, A.A., Cohen, M.X., Sherman, S.J. & Frank, M.J. (2008). A role for dopamine in temporal decision making and reward maximization in Parkinsonism. Journal of Neuroscience, 28, 12294-12304.
[PDF] [Abstract] Santesso, D., Evins, A., Frank, M., Cowman, E. & Pizzagalli, D. (2009). Single dose of a dopamine agonist impairs reinforcement learning in humans: Converging evidence from electrophysiology and computational modeling of striatal-cortical function. Human Brain Mapping, 30, 1963--1976.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Samanta, J., Moustafa, A.A. & Sherman, S.J. (2007). Hold your horses: Impulsivity, deep brain stimulation and medication in Parkinsonism. Science, 318, 1309-1312. [Journal Homepage]
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Moustafa, A.A., Haughey, H., Curran, T. & Hutchison, K. (2007). Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning. Proceedings of the National Academy of Sciences, 104, 16311-16316. [Journal Homepage]
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Scheres, A. & Sherman, S.J. (2007). Understanding decision making deficits in neurological conditions: Insights from models of natural action selection. Philosophical Transactions of the Royal Society - B, 362, 1641-1654. [Journal Homepage]
[Main PDF] [Supp PDF] [Abstract] Hazy, T.E., Frank, M.J. & O'Reilly, R.C. (2007). Toward an executive without a homunculus: Computational models of the prefrontal cortex/basal ganglia system. Philosophical Transactions of the Royal Society - B, 362, 1601-1613. [Journal Homepage]
[PDF] [Abstract] O'Reilly, R.C., Frank, M.J., Hazy, T.E. & Watz, B. (2007). PVLV: The Primary Value and Learned Value Pavlovian learning algorithm. Behavioral Neuroscience, 121, 31-49.
[PDF] [Abstract] Frank, M.J. (2006). Hold your horses: A dynamic computational role for the subthalamic nucleus in decision making. Neural Networks, 19, 1120-1136.
[PDF] [Abstract] Frank, M.J. & Claus, E.D. (2006). Anatomy of a decision: Striato-orbitofrontal interactions in reinforcement learning, decision making and reversal. Psychological Review, 113, 300-326.
[PDF] [Abstract] O'Reilly, R.C. & Frank, M.J. (2006). Making working memory work: A computational model of learning in the frontal cortex and basal ganglia. Neural Computation, 18, 283-328.
[PDF] [Abstract] Hazy, T.E., Frank, M.J. & O'Reilly, R.C. (2006). Banishing the homunculus: Making working memory work. Neuroscience, 139, 105--118.
[PDF] [Abstract] Frank, M.J. (2005). Dynamic dopamine modulation in the basal ganglia: A neurocomputational account of cognitive deficits in medicated and non-medicated Parkinsonism. Journal of Cognitive Neuroscience, 17, 51-72.
[PDF] [Abstract] Atallah, H.E., Frank, M.J. & O'Reilly, R.C. (2004). Hippocampus, cortex and basal ganglia: Insights from computational models of complementary learning systems. Neurobiology of Learning and Memory, 82/3, 253-67.
[PDF] [Abstract] Frank, M.J., Rudy, J.W. & O'Reilly, R.C. (2003). Transitivity, flexibility, conjunctive representations and the hippocampus: II. A computational analysis. Hippocampus, 13, 341-354.
[PDF] [Abstract] Frank, M.J., Loughry, B. & O'Reilly, R.C. (2001). Interactions between the frontal cortex and basal ganglia in working memory: A computational model. Cognitive, Affective, and Behavioral Neuroscience, 1, 137-160.

Empirical

[Main PDF] [Supp PDF] [Abstract] Gold, J.M., Waltz, J.A., Matveeva, T.M., Kasanova, Z., Strauss, G.P., Herbener, E.S., Collins, A.G.E. & Frank, M.J. (2012). Negative symptoms and the failure to represent the expected reward value of actions: Behavioral and computational modeling evidence. Archives of General Psychiatry, 69, 129-138.
[PDF] [Abstract] Badre, D. & Frank, M.J. (2012). Mechanisms of hierarchical reinforcement learning in corticostriatal circuits 2: Evidence from fMRI. Cerebral Cortex, 22, 527-536.
[PDF] [Abstract] Doll, B.B., Hutchison, K.E. & Frank, M.J. (2011). Dopaminergic genes predict individual differences in susceptibility to confirmation bias. Journal of Neuroscience 6188-6198.
[PDF] [Abstract] Cavanagh, J.F., Bismark, A.J., Frank, M.J. & Allen, J.J.B. (2011). Larger error signals in major depression are associated with better avoidance learning. Frontiers in Psychology | Cognition, 2,.
[PDF] [Abstract] Strauss, G.P., Frank, M.J., Waltz, J.A., Kasanova, Z., Herbener, E.S. & Gold, J.M. (2011). Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia. Biological Psychiatry, 69, 424-431.
[PDF] [Abstract] Kasanova, Z., Waltz, J.A., Strauss, G.P., Frank, M.J. & Gold, J.M. (2011). Optimizing vs matching: Response strategy in a probabilistic learning task is associated with negative symptoms of schizophrenia. Schizophrenia Research, 127, 215-222.
[PDF] [Abstract] Waltz, J.A., Frank, M.J., Wiecki, T.V. & Gold, J.M. (2011). Altered probabilistic learning and response biases in schizophrenia: Behavioral evidence and neurocomputational modeling. Neuropsychology, 25,.
[PDF] [Abstract] Cavanagh, J.F., Frank, M.J. & Allen, J.J.B. (2011). Social stress reactivity alters reward and punishment learning. Social Cognitive & Affective Neuroscience, 6, 311-320.
[PDF] [Abstract] Cavanagh, J.F., Frank, M.J., Klein, T.J. & Allen, J.J.B. (2010). Frontal theta links prediction errors to behavioral adaptation in reinforcement learning. NeuroImage, 49, 3198-3209.
[PDF] [Abstract] Cavanagh, J.F., Grundler, T.O.J., Frank, M.J. & Allen, J.J.B. (2010). Altered cingulate sub-region activation accounts for task-related dissociation in ERN amplitude as a function of obsessive-compulsive symptoms. Neuropsychologia, 48, 2098-2109.
[PDF] [Abstract] Robinson, O.J., Frank, M.J., Sahakian, B.J. & Cools, C. (2010). Dissociable responses to punishment in distinct striatal regions during reversal learning. NeuroImage 1459-1467.
[PDF] [Abstract] Strauss, G.P., Robinson, B.M., Waltz, J.A., Frank, M.J., Kasanova, Z., Herbener, E.S. & Gold, J.M. (in press). Patients with schizophrenia demonstrate inconsistent preference judgments for affective and nonaffective stimuli. Schizophrenia Bulletin.
[PDF] [Abstract] Chase, H.W., Frank, M.J., Michael, A., Bullmore, E.T., Sahakian, B. & Robbins, T.W. (2010). Approach and avoidance learning in patients with major depression and healthy controls: relation to anhedonia. Psychological Medicine, 40, 433-440.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Doll, B.B., Oas-Terpstra, J. & Moreno, F. (2009). Prefrontal and striatal dopaminergic genes predict individual differences in exploration and exploitation. Nature Neuroscience, 12, 1062-1068.
[PDF] [Abstract] Frank, M.J. & Hutchison, K.E. (2009). Genetic contributions to avoidance-based decisions: Striatal D2 receptor polymorphisms. Neuroscience, 164, 131-140.
[PDF] [Abstract] Gruendler, T.O.J., Cavanagh, J.F., Figueroa, C.M., Frank, M.J. & Allen, J.J.B. (2009). Task-related dissociation in ERN amplitude as a function of obsessive-compulsive symptoms. Neuropsychologia, 47, 1978-1987.
[Main PDF] [Supp PDF] [Abstract] Chatham, C.H., Frank, M.J. & Munakata, Y. (2009). Pupillometric and behavioral markers of a developmental shift in the temporal dynamics of cognitive control. Proceedings of the National Academy of Sciences, 106, 5529-5533.
[PDF] [Abstract] Doll, B.B., Jacobs, W.J., Sanfey, A.G. & Frank , M.J. (2009). Instructional control of reinforcement learning: A behavioral and neurocomputational investigation. Brain Research, 1299, 74-94.
[Main PDF] [Supp PDF] [Abstract] Cools, R., Frank, M.J., Gibbs, S.E., Miyakawa, A., Jagust, W. & D'Esposito, M. (2009). Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration. Journal of Neuroscience, 29, 1538-1543.
[PDF] [Abstract] Moustafa, A.A., Cohen, M.X., Sherman, S.J. & Frank, M.J. (2008). A role for dopamine in temporal decision making and reward maximization in Parkinsonism. Journal of Neuroscience, 28, 12294-12304.
[PDF] [Abstract] Moustafa, A.A., Sherman, S.J. & Frank, M.J. (2008). A dopaminergic basis for working memory, learning and attentional shifting in Parkinsonism. Neuropsychologia, 46, 3144-3156.
[PDF] [Abstract] Santesso, D., Evins, A., Frank, M., Cowman, E. & Pizzagalli, D. (2009). Single dose of a dopamine agonist impairs reinforcement learning in humans: Converging evidence from electrophysiology and computational modeling of striatal-cortical function. Human Brain Mapping, 30, 1963--1976.
[PDF] [Abstract] Frank, M.J. & Kong, L. (2008). Learning to Avoid in Older Age. Psychology and Aging, 23, 392-398.
[PDF] [Abstract] Pizzagalli, D.A., Evins, A.E., Schetter, E.C., Frank, M.J., Pajtas, P.E., Santesso, D.L. & Culhane, M. (2008). Single dose of a dopamine agonist impairs reinforcement learning in humans: Behavioral evidence from a laboratory-based measure of reward responsiveness. Psychopharmacology, 196, 221--232.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Samanta, J., Moustafa, A.A. & Sherman, S.J. (2007). Hold your horses: Impulsivity, deep brain stimulation and medication in Parkinsonism. Science, 318, 1309-1312. [Journal Homepage]
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Moustafa, A.A., Haughey, H., Curran, T. & Hutchison, K. (2007). Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning. Proceedings of the National Academy of Sciences, 104, 16311-16316. [Journal Homepage]
[PDF] [Abstract] Frank, M.J., D'Lauro, C. & Curran, T. (2007). Cross-task individual differences in error processing: Neural, electrophysiological and genetic components. Cognitive, Affective and Behavioral Neuroscience, 7, 297-308.
[PDF] [Abstract] Frank, M.J., Santamaria, A., O'Reilly, R. & Willcutt, E. (2007). Testing computational models of dopamine and noradrenaline dysfunction in Attention Deficit/Hyperactivity Disorder. Neuropsychopharmacology, 32, 1583-99.
[Main PDF] [Commentary] [Abstract] Waltz, J.A., Frank, M.J., Robinson, B.M. & Gold, J.M. (2007). Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction. Biological Psychiatry, 62, 756-764.
[PDF] [Abstract] Aron, A.R., Behrens, T.E., Smith, S., Frank, M.J. & Poldrack, R.A. (2007). Triangulating a cognitive control network using diffusion-weighted MRI and functional MRI. Journal of Neuroscience, 27, 3743-52.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J. & O'Reilly, R.C. (2006). A mechanistic account of striatal dopamine function in human cognition: Psychopharmacological studies with cabergoline and haloperidol. Behavioral Neuroscience, 120, 497-517.
[PDF] [Abstract] Frank, M.J., OReilly, R.C. & Curran, T. (2006). When memory fails, intuition reigns: Midazolam enhances implicit inference in humans. Psychological Science, 17, 700-707.
[PDF] [Abstract] Frank, M.J., Rudy, J.W., Levy, W.B. & O'Reilly, R.C. (2005). When logic fails: Implicit transitive inference in humans. Memory and Cognition, 33, 742--750.
[PDF] [Abstract] Frank, M.J., Woroch, B.S. & Curran, T. (2005). Error-related negativity predicts reinforcement learning and conflict biases. Neuron, 47, 495-501.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Seeberger, L. & O'Reilly, R.C. (2004). By carrot or by stick: Cognitive reinforcement learning in Parkinsonism. Science, 306, 1940-1943.

Basal Ganglia and Frontal Cortex Contributions to Reinforcement Learning and Decision Making

[PDF] [Abstract] Collins, A.G.E. & Frank, M.J. (2012). How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis. European Journal of Neuroscience, 35, 1024-1035.
[Main PDF] [Supp PDF] [Abstract] Cavanagh, J.F., Wiecki, T.V., Cohen, M.X., Figueroa, C.M., Samanta, J., Sherman, S.J. & Frank, M.J. (2011). Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold. Nature Neuroscience, 14,.
[PDF] [Abstract] Ratcliff, R. & Frank, M.J. (2012). Reinforcement-based decision making in corticostriatal circuits: Mutual constraints by neurocomputational and diffusion models. Neural Computation, 24, 1186-1229.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J. & Badre, D. (2012). Mechanisms of hierarchical reinforcement learning in corticostriatal circuits 1: Computational analysis. Cerebral Cortex, 22, 509-526.
[PDF] [Abstract] Doll, B.B., Hutchison, K.E. & Frank, M.J. (2011). Dopaminergic genes predict individual differences in susceptibility to confirmation bias. Journal of Neuroscience 6188-6198.
[PDF] [Abstract] Frank, M.J. (2011). Computational models of motivated action selection in corticostriatal circuits. Current Opinion in Neurobiology, 21, 381-386.
[PDF] [Abstract] Maia, T.V. & Frank, M.J. (2011). From reinforcement learning models to psychiatric and neurological disorders. Nature Neuroscience, 14, 154-162.
[PDF] [Abstract] Frank, M.J. & Fossella, J.A. (2011). Neurogenetics and pharmacology of learning, motivation and cognition. Neuropsychopharmacology Reviews, 36, 133-152.
[PDF] [Abstract] Cockburn, J. & Frank, M.J. (2011). Reinforcement learning, conflict monitoring, and cognitive control: An integrative model of cingulate-striatal interactions and the ERN. R. Mars, J. Sallet, M. Rushworth & N. Yeung (Eds) Neural Basis of Motivational and Cognitive Control, 311-331, Cambridge: The MIT Press.
[PDF] [Abstract] Wietzikoski, E.C., Boschen, S.L., Miyoshi, E., Bortolanza, M., Mendes dos Santos, L., Frank, M.J., Brandao, M.L., Winn, P. & Da Cunha, C. (in press). Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses. Psychopharmacology.
[PDF] [Abstract] Wiecki, T.V. & Frank, M.J. (2010). Neurocomputational models of motor and cognitive deficits in Parkinson's disease. Progress in Brain Research, 183, 275-297.
[PDF] [Abstract] Cavanagh, J.F., Frank, M.J., Klein, T.J. & Allen, J.J.B. (2010). Frontal theta links prediction errors to behavioral adaptation in reinforcement learning. NeuroImage, 49, 3198-3209.
[PDF] [Abstract] Robinson, O.J., Frank, M.J., Sahakian, B.J. & Cools, C. (2010). Dissociable responses to punishment in distinct striatal regions during reversal learning. NeuroImage 1459-1467.
[PDF] [Abstract] Samson, R.D., Frank, M.J. & Fellous, J. (2010). Computational models of reinforcement learning: the role of dopamine as a reward signal. Cognitive Neurodynamics, 4, 91-105.
[PDF] [Abstract] Hazy, T.E., Frank, M.J. & O'Reilly, R.C. (2010). Neural mechanisms of acquired phasic dopamine responses in learning. Neuroscience & Biobehavioral Reviews, 34, 701-720.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Doll, B.B., Oas-Terpstra, J. & Moreno, F. (2009). Prefrontal and striatal dopaminergic genes predict individual differences in exploration and exploitation. Nature Neuroscience, 12, 1062-1068.
[PDF] Daw, N.D. & Frank, M.J. (2009). Reinforcement learning and higher level cognition: Introduction to special issue. Cognition, 113, 259-261.
[PDF] Frank, M.J. & Surmeier, D.J. (2009). Do substantia nigra dopaminergic neurons differentiate between reward and punishment? (Commentary on Matsumoto & Hikosaka, 2009). Journal of Molecular Cell Biology, 1, 15-16.
[email me for PDF] [Abstract] Doll, B.B. & Frank, M.J. (2009). The basal ganglia in reward and decision making: computational models and empirical studies. J. Dreher & L. Tremblay (Eds) Handbook of Reward and Decision Making, 399-425, Oxford: Academic Press.
[PDF] [Abstract] Frank, M.J. & Hutchison, K.E. (2009). Genetic contributions to avoidance-based decisions: Striatal D2 receptor polymorphisms. Neuroscience, 164, 131-140.
[PDF] Frank, M.J. (2009). Slave to the striatal habit (Commentary on Tricomi et al, 2009). European Journal of Neuroscience, 29, 2223-2224.
[Main PDF] [Supp PDF] [Abstract] Wiecki, T.V., Riedinger, K., Meyerhofer, A., Schmidt, W. & Frank, M.J. (2009). A neurocomputational account of catalepsy sensitization induced by D2-receptor-blockade in rats: Context-dependency, extinction, and renewal. Psychopharmacology, 204, 265--277.
[PDF] [Abstract] Doll, B.B., Jacobs, W.J., Sanfey, A.G. & Frank , M.J. (2009). Instructional control of reinforcement learning: A behavioral and neurocomputational investigation. Brain Research, 1299, 74-94.
[PDF] [Abstract] Frank, M.J., Cohen, M.X. & Sanfey, A.G. (2009). Multiple systems in decision making: A neurocomputational perspective. Current Directions in Psychological Science, 18, 73--77.
[Main PDF] [Supp PDF] [Abstract] Cools, R., Frank, M.J., Gibbs, S.E., Miyakawa, A., Jagust, W. & D'Esposito, M. (2009). Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration. Journal of Neuroscience, 29, 1538-1543.
[PDF] [Abstract] Cohen, M.X. & Frank, M.J. (2009). Neurocomputational models of basal ganglia function in learning, memory and choice. Behavioural Brain Research, 199, 141-156.
[PDF] [Abstract] Moustafa, A.A., Cohen, M.X., Sherman, S.J. & Frank, M.J. (2008). A role for dopamine in temporal decision making and reward maximization in Parkinsonism. Journal of Neuroscience, 28, 12294-12304.
[PDF] Frank, M.J. (2008). Schizophrenia: A computational reinforcement learning perspective. Schizophrenia Bulletin, 34, 1008-1011.
[PDF] [Abstract] Santesso, D., Evins, A., Frank, M., Cowman, E. & Pizzagalli, D. (2009). Single dose of a dopamine agonist impairs reinforcement learning in humans: Converging evidence from electrophysiology and computational modeling of striatal-cortical function. Human Brain Mapping, 30, 1963--1976.
[PDF] [Abstract] Frank, M.J. & Kong, L. (2008). Learning to Avoid in Older Age. Psychology and Aging, 23, 392-398.
[PDF] [Abstract] Pizzagalli, D.A., Evins, A.E., Schetter, E.C., Frank, M.J., Pajtas, P.E., Santesso, D.L. & Culhane, M. (2008). Single dose of a dopamine agonist impairs reinforcement learning in humans: Behavioral evidence from a laboratory-based measure of reward responsiveness. Psychopharmacology, 196, 221--232.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Samanta, J., Moustafa, A.A. & Sherman, S.J. (2007). Hold your horses: Impulsivity, deep brain stimulation and medication in Parkinsonism. Science, 318, 1309-1312. [Journal Homepage]
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Moustafa, A.A., Haughey, H., Curran, T. & Hutchison, K. (2007). Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning. Proceedings of the National Academy of Sciences, 104, 16311-16316. [Journal Homepage]
[PDF] [Abstract] Frank, M.J., D'Lauro, C. & Curran, T. (2007). Cross-task individual differences in error processing: Neural, electrophysiological and genetic components. Cognitive, Affective and Behavioral Neuroscience, 7, 297-308.
[PDF] [Abstract] Frank, M.J., Santamaria, A., O'Reilly, R. & Willcutt, E. (2007). Testing computational models of dopamine and noradrenaline dysfunction in Attention Deficit/Hyperactivity Disorder. Neuropsychopharmacology, 32, 1583-99.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Scheres, A. & Sherman, S.J. (2007). Understanding decision making deficits in neurological conditions: Insights from models of natural action selection. Philosophical Transactions of the Royal Society - B, 362, 1641-1654. [Journal Homepage]
[Main PDF] [Commentary] [Abstract] Waltz, J.A., Frank, M.J., Robinson, B.M. & Gold, J.M. (2007). Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction. Biological Psychiatry, 62, 756-764.
[PDF] [Abstract] Aron, A.R., Behrens, T.E., Smith, S., Frank, M.J. & Poldrack, R.A. (2007). Triangulating a cognitive control network using diffusion-weighted MRI and functional MRI. Journal of Neuroscience, 27, 3743-52.
[PDF] [Abstract] O'Reilly, R.C., Frank, M.J., Hazy, T.E. & Watz, B. (2007). PVLV: The Primary Value and Learned Value Pavlovian learning algorithm. Behavioral Neuroscience, 121, 31-49.
[PDF] [Abstract] Frank, M.J. (2006). Hold your horses: A dynamic computational role for the subthalamic nucleus in decision making. Neural Networks, 19, 1120-1136.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J. & O'Reilly, R.C. (2006). A mechanistic account of striatal dopamine function in human cognition: Psychopharmacological studies with cabergoline and haloperidol. Behavioral Neuroscience, 120, 497-517.
[PDF] [Abstract] Frank, M.J. & Claus, E.D. (2006). Anatomy of a decision: Striato-orbitofrontal interactions in reinforcement learning, decision making and reversal. Psychological Review, 113, 300-326.
[PDF] [Abstract] Frank, M.J., OReilly, R.C. & Curran, T. (2006). When memory fails, intuition reigns: Midazolam enhances implicit inference in humans. Psychological Science, 17, 700-707.
[PDF] [Abstract] Frank, M.J. (2005). Dynamic dopamine modulation in the basal ganglia: A neurocomputational account of cognitive deficits in medicated and non-medicated Parkinsonism. Journal of Cognitive Neuroscience, 17, 51-72.
[PDF] [Abstract] Frank, M.J., Woroch, B.S. & Curran, T. (2005). Error-related negativity predicts reinforcement learning and conflict biases. Neuron, 47, 495-501.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J., Seeberger, L. & O'Reilly, R.C. (2004). By carrot or by stick: Cognitive reinforcement learning in Parkinsonism. Science, 306, 1940-1943.
[PDF] [Abstract] Frank, M.J. (2004). Dynamic dopamine modulation of striato-cortical circuits in cognition: Converging neuropsychological, psychopharmacological and computational studies. Phd Thesis, University of Colorado at Boulder, Boulder, CO
[PDF] [Abstract] Atallah, H.E., Frank, M.J. & O'Reilly, R.C. (2004). Hippocampus, cortex and basal ganglia: Insights from computational models of complementary learning systems. Neurobiology of Learning and Memory, 82/3, 253-67.

Working Memory and Cognitive Control in the Prefrontal Cortex and Basal Ganglia

[PDF] [Abstract] Collins, A.G.E. & Frank, M.J. (2012). How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis. European Journal of Neuroscience, 35, 1024-1035.
[PDF] [Abstract] Cavanagh, J.F., Figueroa, C.M., Cohen, M.X. & Frank, M.J. (in press). Frontal theta reflects uncertainty and unexpectedness during exploration and exploitation. Cerebral Cortex.
[Main PDF] [Supp PDF] [Abstract] Badre, D., Doll, B.B., Long, N.M. & Frank, M.J. (2012). Rostrolateral prefrontal cortex and individual differences in uncertainty-driven exploration. Neuron, 73, 595-607.
[Main PDF] [Supp PDF] [Abstract] Cavanagh, J.F., Wiecki, T.V., Cohen, M.X., Figueroa, C.M., Samanta, J., Sherman, S.J. & Frank, M.J. (2011). Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold. Nature Neuroscience, 14,.
[Main PDF] [Supp PDF] [Abstract] Frank, M.J. & Badre, D. (2012). Mechanisms of hierarchical reinforcement learning in corticostriatal circuits 1: Computational analysis. Cerebral Cortex, 22, 509-526.
[PDF] [Abstract] Badre, D. & Frank, M.J. (2012). Mechanisms of hierarchical reinforcement learning in corticostriatal circuits 2: Evidence from fMRI. Cerebral Cortex, 22, 527-536.
[Main PDF] [Supp PDF] [Abstract] Chatham, C.H., Frank, M.J. & Munakata, Y. (2009). Pupillometric and behavioral markers of a developmental shift in the temporal dynamics of cognitive control. Proceedings of the National Academy of Sciences, 106, 5529-5533.
[PDF] [Abstract] Moustafa, A.A., Sherman, S.J. & Frank, M.J. (2008). A dopaminergic basis for working memory, learning and attentional shifting in Parkinsonism. Neuropsychologia, 46, 3144-3156.
[PDF] [Abstract] Frank, M.J., Santamaria, A., O'Reilly, R. & Willcutt, E. (2007). Testing computational models of dopamine and noradrenaline dysfunction in Attention Deficit/Hyperactivity Disorder. Neuropsychopharmacology, 32, 1583-99.
[Main PDF] [Supp PDF] [Abstract] Hazy, T.E., Frank, M.J. & O'Reilly, R.C. (2007). Toward an executive without a homunculus: Computational models of the prefrontal cortex/basal ganglia system. Philosophical Transactions of the Royal Society - B, 362, 1601-1613. [Journal Homepage]
[Main PDF] [Supp PDF] [Abstract] Frank, M.J. & O'Reilly, R.C. (2006). A mechanistic account of striatal dopamine function in human cognition: Psychopharmacological studies with cabergoline and haloperidol. Behavioral Neuroscience, 120, 497-517.
[PDF] [Abstract] Frank, M.J. & Claus, E.D. (2006). Anatomy of a decision: Striato-orbitofrontal interactions in reinforcement learning, decision making and reversal. Psychological Review, 113, 300-326.
[PDF] [Abstract] O'Reilly, R.C. & Frank, M.J. (2006). Making working memory work: A computational model of learning in the frontal cortex and basal ganglia. Neural Computation, 18, 283-328.
[PDF] [Abstract] Hazy, T.E., Frank, M.J. & O'Reilly, R.C. (2006). Banishing the homunculus: Making working memory work. Neuroscience, 139, 105--118.
[PDF] [Abstract] Frank, M.J. (2004). Dynamic dopamine modulation of striato-cortical circuits in cognition: Converging neuropsychological, psychopharmacological and computational studies. Phd Thesis, University of Colorado at Boulder, Boulder, CO
[PDF] [Abstract] Frank, M.J., Loughry, B. & O'Reilly, R.C. (2001). Interactions between the frontal cortex and basal ganglia in working memory: A computational model. Cognitive, Affective, and Behavioral Neuroscience, 1, 137-160.

Learning, Memory and Generalization in the Hippocampus

[PDF] [Abstract] Frank, M.J., O'Reilly, R. & Curran, T. (2008). Midazolam, hippocampal function, and transitive inference: Reply to Greene. Behavioral and Brain Functions, 4, 5.
[PDF] [Abstract] Frank, M.J., OReilly, R.C. & Curran, T. (2006). When memory fails, intuition reigns: Midazolam enhances implicit inference in humans. Psychological Science, 17, 700-707.
[PDF] [Abstract] Frank, M.J., Rudy, J.W., Levy, W.B. & O'Reilly, R.C. (2005). When logic fails: Implicit transitive inference in humans. Memory and Cognition, 33, 742--750.
[PDF] [Abstract] Atallah, H.E., Frank, M.J. & O'Reilly, R.C. (2004). Hippocampus, cortex and basal ganglia: Insights from computational models of complementary learning systems. Neurobiology of Learning and Memory, 82/3, 253-67.
[PDF] [Abstract] Frank, M.J., Rudy, J.W. & O'Reilly, R.C. (2003). Transitivity, flexibility, conjunctive representations and the hippocampus: II. A computational analysis. Hippocampus, 13, 341-354.

Commentaries

[PDF] Daw, N.D. & Frank, M.J. (2009). Reinforcement learning and higher level cognition: Introduction to special issue. Cognition, 113, 259-261.
[PDF] Frank, M.J. & Surmeier, D.J. (2009). Do substantia nigra dopaminergic neurons differentiate between reward and punishment? (Commentary on Matsumoto & Hikosaka, 2009). Journal of Molecular Cell Biology, 1, 15-16.
[PDF] Frank, M.J. (2009). Slave to the striatal habit (Commentary on Tricomi et al, 2009). European Journal of Neuroscience, 29, 2223-2224.

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